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Literature summary for 2.3.1.5 extracted from
- Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation Role in the regulation of p53 stability (2018), PLoS ONE, 13, e0193560 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P18440 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | upon knockout of NAT1 in HT-29 and HeLa cells, cell growth decreases in both cell-lines during glucose starvation, but it is enhanced in HT-29 cells following NAT1 deletion. This is due to an increase in ROS production that induces cell apoptosis. Both ROS production and cell death are prevented by N-acetylcysteine. NAT1 knockout also results in a loss of the gain-of-function p53 protein in HT-29 cells | Homo sapiens |
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Release 2023.1 (January 2023)
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